one. How practise BMC stalk prison cell injections, platelet rich plasma (PRP) injections and amniotic fluid-derived allografts accelerate the healing process of orthopedic injuries?

Platelet rich plasma (PRP), BMC (bone marrow concentrate) stalk cell injections and amniotic fluid-derived allografts (such as Orthoflo) all apply the latest in medical technology when combined with the body's natural healing abilities. When the body becomes injured, information technology initiates a healing response that includes rebuilding of import tissue with the use of cells and growth factors.

Growth factors are characterized equally small-scale signaling proteins that assist the body initiate and control the healing process. Mesenchymal stem cells (MSC) are specific cells to the musculoskeletal arrangement, which are able to differentiate into different tissue types such equally ligament, tendon, muscle and even bone. By providing these cells or growth factors to the injured site, Dr. Matthew Provencher may be able to help decrease inflammation, improve or advance healing and allow for pain relief and/or a quicker recovery.

2. Are BMC stem cell injections, platelet rich plasma (PRP) and allografts all considered regenerative therapies?

The elementary answer is no. While PRP accelerates the trunk's ability to heal itself through the help of growth factors, it is not considered a regenerative therapy.

BMC and amniotic-fluid derived allografts on the other manus are considered regenerative therapies considering they are believed to help with both healing acceleration and tissue regeneration. The additional "pluripotent" adult stalk cells withdrawn from the patient, typically from a patient'due south own iliac pelvic bone, used for the BMC process are "undifferentiated," meaning they are able to replicate themselves into (or regenerate) various types of tissue. Amniotic-fluid derived allografts contain cells and growth factors from donor tissue, specifically placenta and amniotic fluid.

3. Why is bone marrow concentrate (BMC) called a stem cell "like" therapy?

The term "stem jail cell therapy" is often associated with controversial treatments using embryonic or fetal stem cells collected from aborted fetal tissue. By using a patient's own "pluripotent" adult stem cells or placental tissues, the BMC stem cell injections utilized by Dr. Provencher tin can replicate the same benefits of stem cell therapy without the ethical concerns of using embryonic/fetal stalk cells.

iv. Is at that place an age limit for BMC stem cell injections?

In that location is not an historic period limit for BMC stem prison cell injections, but certain factors should be considered in patients over the age of 60 years.

Patients upwards to the historic period of lx tin mostly achieve tissue regeneration using their ain "pluripotent" adult stem cells through BMC therapy.

Unfortunately, as the body ages, its power to regenerate tissue from autologous (its own) stalk cells diminishes. It is reported the body'due south number of stem cells begins to decrease with historic period starting at about 40 years. After age 60, autologous BMC typically fails to provide regeneration considering there are not enough stem cells in the bone marrow. Between the ages of seventy and 80 years, there are almost no stalk cells in the bone marrow to use. Subsequently age 80, stem cells in the bone marrow are virtually not-existent.

Due to this decline in autologous stem cells, patients over 60 years of age generally achieve ameliorate results using a combination of a healing accelerator, such as PRP or an amniotic-fluid derived allograft, and allograft tissues derived from another source for regeneration.

5. Practise all platelet rich plasma (PRP) and bone marrow concentrate (BMC) stem cell therapies provide the aforementioned healing and regeneration benefits?

The answer is no. It is very important patients considering PRP and BMC therapies understand the doctors who administrate these treatments buy kits to concentrate and prepare the claret or os marrow for the injections. As the regenerative orthopedic treatments continue to proceeds popularity throughout the land, in that location are more than companies that sell these kits. It is of import to note that just a small number of companies have received FDA approval for their treatments. This means that some physicians are using kits that are not FDA canonical, or kits that provide significantly less concentrations of cells than the approved kits.

Enquiry shows that the minimum level for the concentration of platelets necessary to reach positive results from platelet rich plasma injections are 5-7 times that of the human blood platelet count. Studies conducted in head to caput comparisons have repeatedly shown that inexpensive and inferior kits used by some physicians simply produce two-3 times the blood platelet concentration. It is very important that patients inquire if the kits their physicians are using are FDA approved and if they are meeting the concentration levels necessary for a positive outcome.

The PRP kits used by Dr. Provencher and his orthopedic squad are FDA approved and produce at least seven-9 times concentrate of platelets. The BMC kits are ane of very few approved by the FDA and consistently produce higher counts of nucleated stem cells than the competitors' kits in head to head studies.

6. Why doesn't my insurance encompass this treatment?

Since regenerative orthopedic treatments are still considered experimental, insurance does not cover them. Cash pay is required at this time.

To acquire more about the affects of biologics in sports medicine, please visit the biologic research department of our website: Biologic Research.

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